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Isotopic Polymorphism in Pyridine†

Crawford, S., Kirchner, Michael T., Bläser, D., Boese, R., David, William I. F., Dawson, A., Gehrke, A.,Ibberson, Richard M., Marshall, William G., Parsons, S. and Yamamuro, O.

 

Angew. Chem. Int. Ed. 2009,121,769-771

[DOI: 10.1002/ ange.200803589]

 

†Dedicated to Dr. Frank Allen on the occasion of his retirement as Executive Director of the Cambridge Crystallographic Data Centre. We thank Prof. G R. Desiraju for suggesting crystallization of [D5]pyridine and STFC for provision of neutron beam time and a studentship for S.C. R.B. gratefully acknowledges the support of the DFG FOR 618.


Abstract

Not so simple: It is normally assumed that deuteration has only a minor effect on the stabilities of crystal structures. This assumption is wrong for pyridine. A low-temperature polymorph exists for [D5]pyridine, but not for [H5]pyridine, which adds a further twist to the already unusual structural chemistry of one of the simplest and most familiar laboratory chemicals.

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